The January 4, 2011 Mega Millions drawing drew attention for its similarity to "The Numbers," a sequence of six numbers that served as a plot device of the ABC drama series Lost. One such usage involved character Hugo "Hurley" Reyes playing the sequence in a similar "Mega Lotto" game, winning a nine-figure jackpot and subsequently experiencing numerous misfortunes in his personal life. The first three numbers (4, 8, 15) and mega ball (42) in the Mega Millions drawing matched the first three numbers and the final number (which Hurley also used as the "mega ball" number) in the Lost sequence. The last two numbers in the Mega Millions drawing did not match the last two numbers that were used in the scene. Those who played "The Numbers", including from quick-picks, won $150 ($118 in California) in a non-Megaplier game; $600 with the multiplier.[46]

On March 13, 2010, New Jersey became the first Mega Millions participant (just before the cross-sell expansion) to produce a jackpot-winning ticket for Powerball after joining that game. The ticket was worth over $211 million annuity (the cash option was chosen). On May 28, 2010, North Carolina became the first Powerball member (just before the cross-selling expansion) to produce a jackpot-winning Mega Millions ticket after joining Mega Millions, with an annuity jackpot of $12 million.
Unclaimed prizes are kept by the lottery jurisdiction. If a Grand Prize goes unclaimed, the money must be returned to all lotteries in proportion to their sales for the draw run. The lotteries then distribute the money, based on their own jurisdiction's laws, to other lottery games or to their jurisdiction's general fund, or otherwise as required by law.
In California, prize levels are paid on a parimutuel basis, rather than the fixed lower-tier amounts for winners in other Mega Millions jurisdictions. California's eight lower-tier Mega Millions prize pools are separate from those shared by the other 45 lotteries. California's second prize is a "secondary jackpot"; its payout sometimes exceeds $1 million cash, even though California does not offer the Megaplier.[33]

The structure of the draw is one which regular lottery players will be very familiar with; players must pick 5 regular numbers from a pool with a total of 69 numbers and in addition to these regular number picks, you also choose one bonus ball (known as the Powerball) from a pool of 26. These two pools of numbers are mutually exclusive and remain completely separate throughout the drawing procedure. In order to jackpot the US Powerball, you need to match all 5 regular numbers and the Powerball. Do this and you are instant Powerball millionaire – it’s as simple as that!